Currently, there is low certainty evidence showing that any exercise is better than standard care for disability in the short and longer terms, however; the effects on pain are more likely at longer term.

Low certainty evidence that manual therapy is better than standard obstetric care but there is conflicting evidence for comparisons with other interventions.

The education provided in this study is no better than standard care.

We describe the burden of chronic low back pain as a component of multimorbidity.

We outline the key role of physical activity and exercise for addressing this burden.

We discuss key considerations for clinicians for managing these individuals.

We illustrate our proposed approach with a case study.

Patient and Public Involvement in Research (PPI) is an evolving concept around the world and is a key driver of equity and social justice

PPI in Research ensures that research reflects the needs and values of those it serves.

Proper training on how to use PPI in research should be made mandatory for researchers, patients, and the public.

Low- and middle-income countries, like Brazil, must encourage the implementation of PPI in health-related research studies.