Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia due to changes in the hormone insulin. The most common type is type 2(DM2), which has insulin resistance as one of its manifestations. Several metabolic changes affect these patients, including endothelial dysfunction and vascular and neurological disorders, as well as impact on quality of life, mental health, and sleep. Pharmacological therapy is one of the main interventions, associated with adaptations in the diet and physical activity routine. However, patients with DM2 do not adhere to treatment for various reasons and the disease continues its progression, burdening the entire health system and impacting the lives of this individual and his entire community. Photobiomodulation therapy (PBMT) appears as an alternative because it acts on energy metabolism, the side effects are negligible, and its non-invasive application can favor adherence. Several scientific studies have shown its effectiveness in glycemic control in an experimental model and the first studies with humans are beginning to emerge to consolidate this possibility.

To verify the effects of PBMT by infrared LED on blood glucose levels and consequent impact on the biopsychosocial context of patients with DM2. Therefore, initial and final laboratory tests of fasting blood glucose, glycated hemoglobin, HOMA-IR index and application of quality of life and sleep questionnaires, perception of pain, sensitivity and mental health will be carried out.

Randomized, double-blind controlled trial with sham group. Sample space of 36 volunteers diagnosed with DM2, distributed in: sham (irradiation with zero parameters), panel (irradiation by the Joovv Elite system of the whole body) and blanket (irradiation with a flexible blanket prototype applied to the abdomen and bilaterally to the quadriceps femoris, hamstrings, triceps surae, arm and forearm). The volunteers underwent initial and final assessments consisting of laboratory tests (fasting blood glucose, glycated hemoglobin and HOMA-IR index) and questionnaires (Diabetes Quality of Life-Brazil-8, Neuropathic Pain Questionnaire 4, painDETECT, Sleep Quality Index of Pittsburgh, Depression, Anxiety and Stress Scale). Participants will be irradiated (active or not) every other day within a 12-day period.

As this is a study protocol, there are no results, conclusions, and implications to be presented.