Children and adolescents with cancer have to deal with the adverse events of the disease and treatments, and low immunity predisposes them to the development of serious forms of infections, that can cause physical damage, negative repercussions on health care and on the quality of life of them and their caregivers.

To evaluate the quality of life of caregivers of children and adolescents with cancer.

Observational, cross-sectional study, carried out from October to December 2022. We used social media, WhatsApp, and emails to invite caregivers of children and adolescents with cancer aged between 2 and 21 years. The survey was performed remotely, through the application of an online form that contained personal and sociodemographic data, the SF-36 questionnaire for assessing the quality of life of the caregivers.

Thirty caregivers participated in the study, with a higher prevalence of females (86.7%). The caregiver's quality of life averaged 55.15 (SD=20.35), which represents a moderate to low quality of life. The worst quality of life scores of caregivers was observed in the domains "Vitality (45.17±XX)", "Emotional Aspects (45.55±XX)", and "Limitation due to Physical Aspects (48.33±XX)".

The quality of life of the caregivers of children and adolescents with cancer was moderate to low, related to impairment of vitality, emotional aspects, and limitation due to physical aspects. Strategies to improve the quality of life of caregivers of children and adolescents with cancer should be considered, therefore improving the integral care for this population and the caregivers.

Conducting further studies on quality of life in relation to other health conditions that may affect physically and mentally caregivers of individuals with childhood cancer may provide help to develop personalized rehabilitation programs for family's pediatric cancer patients.