The minimal important difference for Glittre-ADL test in patients with chronic obstructive pulmonary disease

array:23 ["pii" => "S1413355518303150" "issn" => "14133555" "doi" => "10.1016/j.bjpt.2018.11.009" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "185" "copyright" => "Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia" "copyrightAnyo" => "2018" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Braz J Phys Ther. 2020;24:54-60" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1115 "formatos" => array:3 [ "EPUB" => 102 "HTML" => 601 "PDF" => 412 ] ] "itemSiguiente" => array:18 [ "pii" => "S1413355518303824" "issn" => "14133555" "doi" => "10.1016/j.bjpt.2018.11.008" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "184" "copyright" => "Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Braz J Phys Ther. 2020;24:61-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1000 "formatos" => array:3 [ "EPUB" => 110 "HTML" => 568 "PDF" => 322 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "Original Research" "titulo" => "How does context influence arm use after stroke? A qualitative content analysis among rural community-dwelling stroke survivors" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "61" "paginaFinal" => "68" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Vasanthan Rajagopalan, Manikandan Natarajan, Johnson Alex, John M. Solomon" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Vasanthan" "apellidos" => "Rajagopalan" ] 1 => array:2 [ "nombre" => "Manikandan" "apellidos" => "Natarajan" ] 2 => array:2 [ "nombre" => "Johnson" "apellidos" => "Alex" ] 3 => array:2 [ "nombre" => "John M." "apellidos" => "Solomon" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005">•Personal and environmental context influence affected arm use of stroke survivors.</li><li class="elsevierStyleListItem" id="lsti0010">•Rural stroke survivors have limited awareness and knowledge of active functional task practice.</li><li class="elsevierStyleListItem" id="lsti0015">•For recovery of the affected upper extremity, many stroke survivors rely on passive recovery methods.</li><li class="elsevierStyleListItem" id="lsti0020">•Self-engagement in active functional task practice is facilitated by an enriched home environment and perception of ongoing recovery.</li></ul>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1413355518303824?idApp=UINPBA00007O" "url" => 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] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "46" "paginaFinal" => "53" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1392 "Ancho" => 2333 "Tamanyo" => 180129 ] ] "descripcion" => array:1 [ "en" => "Flow diagram." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luciana De Michelis Mendonça, Natália Franco Netto Bittencourt, Laís Emanuelle Meira Alves, Renan Alves Resende, Fábio Viadanna Serrão" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Luciana De Michelis" "apellidos" => "Mendonça" ] 1 => array:2 [ "nombre" => "Natália Franco Netto" "apellidos" => "Bittencourt" ] 2 => array:2 [ "nombre" => "Laís Emanuelle Meira" "apellidos" => "Alves" ] 3 => array:2 [ "nombre" => "Renan Alves" "apellidos" => "Resende" ] 4 => array:2 [ "nombre" => "Fábio Viadanna" "apellidos" => "Serrão" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005">•Education, joint stabilization, and myofascial release were most used for patellar tendinopathy rehabilitation.</li><li class="elsevierStyleListItem" id="lsti0010">•Quadriceps eccentrics, education, joint stabilization and lumbo-pelvic stabilization and hamstrings stretching were frequently used for patellar tendinopathy prevention.</li><li class="elsevierStyleListItem" id="lsti0015">•Brazilian physical therapists consider pain, function and functional test results to discharge an athlete.</li><li class="elsevierStyleListItem" id="lsti0020">•Our results revealed an inconsistency between interventions used in clinical practice and interventions recommended by the best available evidence.</li></ul>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1413355518302247?idApp=UINPBA00007O" "url" => "/14133555/0000002400000001/v1_202001240805/S1413355518302247/v1_202001240805/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "Original Research" "titulo" => "The minimal important difference for Glittre-ADL test in patients with chronic obstructive pulmonary disease" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "54" "paginaFinal" => "60" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Aline Almeida Gulart, Cintia Laura Pereira de Araujo, Anelise Bauer Munari, Karoliny dos Santos, Manuela Karloh, Betina Gabriele Foscarini, Pedro Dal Lago, Anamaria Fleig Mayer" "autores" => array:8 [ 0 => array:3 [ "nombre" => "Aline Almeida" "apellidos" => "Gulart" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "Cintia Laura Pereira de" "apellidos" => "Araujo" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] 2 => array:3 [ "nombre" => "Anelise Bauer" "apellidos" => "Munari" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Karoliny dos" "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Manuela" "apellidos" => "Karloh" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "e" "identificador" => "aff0025" ] ] ] 5 => array:3 [ "nombre" => "Betina Gabriele" "apellidos" => "Foscarini" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 6 => array:3 [ "nombre" => "Pedro" "apellidos" => "Dal Lago" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] 7 => array:4 [ "nombre" => "Anamaria Fleig" "apellidos" => "Mayer" "email" => array:1 [ 0 => "anamaria.mayer@udesc.br" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "e" "identificador" => "aff0025" ] 3 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Center for Assistance, Teaching and Research in Pulmonary Rehabilitation (NuReab), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Human Movement Sciences Graduate Program, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Research Group on Cardiopulmonary Interaction (GPIC), Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Health Sciences Graduate Program, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Physical Therapy Graduate Program, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author at: Núcleo de Assistência, Ensino e Pesquisa em Reabilitação Pulmonar, UDESC, Rua Pascoal Simone 358, CEP 88080-350, Florianópolis, SC, Brazil." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1300 "Ancho" => 1317 "Tamanyo" => 39283 ] ] "descripcion" => array:1 [ "en" => "Receiver operating characteristic curves for change in Glittre-ADL test using the improvement of 30m in the six-minute walk test: AUC of 0.66 (95%CI 0.51–0.81; p=0.037), sensitivity of 64% and specificity of 69%." ] ] ] "textoCompleto" => "IntroductionFunctional limitation is a common and important finding in patients with chronic obstructive pulmonary disease (COPD)<a class="elsevierStyleCrossRef" href="#bib0185">1</a> which is directly related to a reduction in quality of life,<a class="elsevierStyleCrossRef" href="#bib0190">2</a> a higher frequency of exacerbations and hospitalizations<a class="elsevierStyleCrossRef" href="#bib0195">3</a> and increased mortality.<a class="elsevierStyleCrossRef" href="#bib0200">4</a> Therefore, it is an essential aspect of the evaluation routine of pulmonary rehabilitation programs (PRP).<a class="elsevierStyleCrossRef" href="#bib0205">5</a>Field tests are functional status assessment tools capable of objectively assessing patient performance in common daily tasks.<a class="elsevierStyleCrossRef" href="#bib0205">5</a> There are numerous valid tests for patients with COPD, and it is recommended to choose those with well-established measurement properties.<a class="elsevierStyleCrossRef" href="#bib0210">6</a> When the objective is to verify the effect of an intervention, besides the choice of a responsive test, it is necessary to know its minimal important difference (MID), which allows a better interpretation of the results obtained after the intervention.<a class="elsevierStyleCrossRef" href="#bib0215">7</a> The MID is defined as “a meaningful change or effect that might be considered important, beneficial or harmful, either by patients or informed proxies (including clinicians) and which would lead the patient/clinician to consider a change in management”.<a class="elsevierStyleCrossRef" href="#bib0220">8</a> Among the most common functional capacity tests that present MID after PRP, may be highlighted: the six-minute walk test (6MWT),<a class="elsevierStyleCrossRef" href="#bib0210">6</a> the Incremental Shuttle Walking Test<a class="elsevierStyleCrossRef" href="#bib0210">6</a> and the five-repetition sit-to-stand test.<a class="elsevierStyleCrossRef" href="#bib0225">9</a>However, although other tests have well-established measurement properties and are gaining space regarding the functional capacity assessment of patients with COPD, their MID has not been studied yet. In this context, there is the Glittre ADL-test (TGlittre), which is composed by multiple tasks common in daily life, developed, and validated specifically for patients with COPD.<a class="elsevierStyleCrossRefs" href="#bib0230">10,11</a> It is valid<a class="elsevierStyleCrossRef" href="#bib0230">10</a> and reliable for assessing the functional capacity of clinically stable patients<a class="elsevierStyleCrossRefs" href="#bib0230">10,12,13</a> and hospitalized patients.<a class="elsevierStyleCrossRef" href="#bib0250">14</a> TGlittre is responsive to PRP<a class="elsevierStyleCrossRef" href="#bib0230">10</a> and it is able to differentiate the functional capacity of patients with COPD from healthy individuals.<a class="elsevierStyleCrossRef" href="#bib0255">15</a> Also, it correlates with several other instruments for assessing functional status<a class="elsevierStyleCrossRefs" href="#bib0230">10,16–19</a> and health status<a class="elsevierStyleCrossRef" href="#bib0280">20</a> of patients with COPD.Nevertheless, the minimal change required in the TGlittre after an intervention to determine clinically important improvement is still not known. Dechman and Scherer<a class="elsevierStyleCrossRef" href="#bib0190">2</a> suggest that it is approximately 1min, but it has not been formally tested and established. Therefore, the investigation of this response is relevant in order to evidence whether an intervention is capable of individually generating important changes in patient's capacity to perform multiple activities of daily living (ADL).<a class="elsevierStyleCrossRef" href="#bib0285">21</a> This would facilitate the interpretation of the test results after a PRP.Therefore, the aim of the current study was to determine TGlittre MID in patients with COPD. Secondarily, we aimed to analyze the reliability and to compare the learn effect of the time spent in TGlittre pre and post PRP, as well as to investigate its responsivity after a PRP.MethodsSubjectsPatients with COPD (GOLD II-IV)<a class="elsevierStyleCrossRef" href="#bib0185">1</a> were referred to PRP of the Center for Assistance, Teaching and Research in Pulmonary Rehabilitation from the Universidade do Estado de Santa Catarina (NuReab-UDESC) and of the Research Group on Cardiopulmonary Interaction from the Universidade Federal de Ciências da Saúde de Porto Alegre (GPIC-UFCSPA). The inclusion criteria were: clinical diagnosis of COPD confirmed by spirometry; age of 40 years or more and clinical stability in the four weeks prior to the protocol. Were excluded: active smokers, patients with any change in symptoms during the assessment protocol, PRP interruption for any reason, and patients with other respiratory, cardiovascular, neurological, musculoskeletal and/or rheumatologic diseases that could compromise the performance of the evaluations, as well as the physical training established by the PRP.This study was approved by the Ethics Committee on Human Research at UDESC (Florianópolis, Santa Catarina, Brazil), UFCSPA (Porto Alegre, Rio Grande do Sul, Brazil), and Irmandade da Santa Casa de Misericórdia de Porto Alegre (Porto Alegre, Rio Grande do Sul, Brazil) (CAAE 80831117.5.0000.0118, 1.413.342 and 836.248, respectively) and all participants signed the consent form. This study was registered and published in the Clinical Trials (NCT03251781).Study protocolPatients underwent pulmonary function assessment and, on two separate days, 6MWT and TGlittre. Both functional capacity tests were performed before and after 24 training sessions.The pulmonary function test was performed according to the recommendations and criteria of acceptability and reproducibility proposed by the American Thoracic Society/European Respiratory Society.<a class="elsevierStyleCrossRef" href="#bib0290">22</a> Spirometric measurements were obtained before and 15min after the inhalation of 400μg of salbutamol. The predicted values were calculated from the equation proposed for the Brazilian population.<a class="elsevierStyleCrossRef" href="#bib0295">23</a>The TGlittre was executed according to the protocol validated by Skumlien et al.,<a class="elsevierStyleCrossRef" href="#bib0230">10</a> which consists of performing five laps in the shortest possible time in a standardized circuit arranged in a 10-m corridor, carrying a backpack (2.5kg for women and 5.0kg for men). From the seated position, the subject stands up and walks along a flat corridor, in the middle of which there is a 3-step staircase (each step 17cm high×27cm deep) to be climbed. At the end of the corridor, the subject moves three 1-kg objects, positioned on a shelf (shoulders’ height), one by one, to another shelf (waist's height) and then to the floor. Then the objects are placed back on the lower shelf, and finally returned to the upper shelf. The subject returns, in the reverse course, to the initial sitting position. Immediately after sitting down, another lap must be started, following the same circuit.<a class="elsevierStyleCrossRef" href="#bib0230">10</a> Two tests were performed, with a minimum interval of 30min or until the vital signs and symptoms returned to baseline. The test performed in the shortest time was used for the analysis.The 6MWT was used as an anchor and performed as recommended by the American Thoracic Society/European Respiratory Society.<a class="elsevierStyleCrossRef" href="#bib0300">24</a> Two tests were performed, with a minimum interval of 30min or until the signs and symptoms returned to baseline. Before the test, patients were instructed to travel as far as possible, with standardized verbal encouragement every minute. The best performance was considered for the analysis. The MID of 30m was considered as an anchor to determine the TGlittre's MID since it was established based on numerous studies.<a class="elsevierStyleCrossRef" href="#bib0210">6</a>Pulmonary rehabilitation programThe PRP was designed according to the American Thoracic Society/European Respiratory Society guidelines.<a class="elsevierStyleCrossRef" href="#bib0205">5</a> The supervised physical training was conducted over 24 sessions, three times a week. The program included continuous aerobic training on treadmill (30min with training intensity determined by dyspnea sensation between 4 and 6 on the modified Borg scale)<a class="elsevierStyleCrossRef" href="#bib0305">25</a> and resistance training for upper limbs with free weights or elastic bands (movements performed based on the modified diagonals of the proprioceptive neuromuscular facilitation method, performed in two sets, lasting 2min each) and lower limbs training (quadriceps and triceps sural) with free weights and/or in the extensor chair (2 sets of 10–15 repetitions). Initially, lower limbs were exercised with 2-kg and upper limbs were exercised without any external workload. The localized training intensity was increased according to patient's perception of effort and difficulty (easy or difficult). If the exercise was “easy”, the load was increased by 1kg for lower and 0.5kg for upper limbs.Statistical analysisThe data analysis was performed in Statistical Package for Social Sciences (SPSS) 20.0 and GraphPad Prism 5. The Shapiro–Wilk test was used to verify the distribution of the data. The Student's T for paired samples and Wilcoxon tests were used to compare the time spent in TGlittre and the distance in 6MWT before and after PRP. The effect sizes of the change in TGlittre and 6MWT were calculated using Cohen's d statistics. The following classification was considered: small (d=0.2), medium (d=0.5) or large (d≥0.8) effect size.<a class="elsevierStyleCrossRef" href="#bib0310">26</a> Intraclass correlation coefficient (ICC) was used to analyze the reliability of TGlittre (ICC model: “two-way random”; ICC type: “absolute agreement”) and Student's T for paired samples or Wilcoxon tests were used to compare the learn effect of the time spent in TGlittre pre and post PRP. The Spearman correlation coefficient was used to test the correlation between the change in TGlittre and the change in 6MWT and, if there was a correlation ≥0.3,<a class="elsevierStyleCrossRef" href="#bib0215">7</a> the MID of 30 meters for the 6MWT<a class="elsevierStyleCrossRef" href="#bib0210">6</a> would be used as an anchor to determine the TGlittre's MID, using the receiver operating characteristic (ROC) curve. The distribution-based methods used to calculate TGlittre's MID are listed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.<a class="elsevierStyleCrossRefs" href="#bib0310">26–29</a> The Mann–Whitney U-test was used to compare the change in distance walked in 6MWT between patients who achieved or not TGlittre's MID. The association between achieve the TGlittre's MID (yes/no) and achieve the 6MTWT's MID (yes/no) was tested with Chi-square test followed by Cramer's V to demonstrate the magnitude of the association. The significance level was 5%.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Sample sizeThe sample size was calculated in MedCalc 17.1, aiming to achieve an area under the curve (AUC) of 0.70.<a class="elsevierStyleCrossRef" href="#bib0330">30</a> With a bidirectional α=0.05 and β=0.20, the estimated sample size was 60.ResultsFrom a total of 81 patients that engaged the study, 60 (37 men) completed the PRP. The reasons why 21 patients did not complete the PRP were: death (03); started smoking (01); withdrawal (07); severe COPD exacerbation (07); cataract surgery (02); diverticulitis (01). <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows patients’ baseline characteristics. Subjects improved their functional capacity after the PRP (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>), although 25 patients did not achieve the MID for the 6MWT (improvement ≥30m). The effect sizes of TGlittre and 6MWT improvement were similar (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). Patients who achieved the MID of 6MWT improved −0.33min (95%CI −0.76 to −0.08min; p=0.038) more in TGlittre when compared to those that did not achieve.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia>The baseline TGlittre and 6MWT presented a negative correlation (r=−0.78; p<0.001), and the change in the TGlittre correlated with the change in the 6MWT (r=−0.31; p=0.015); therefore, it was used as the reliable anchor.<a class="elsevierStyleCrossRef" href="#bib0215">7</a> The ROC curve indicated a cutoff value for a clinically significant change in the TGlittre of −0.38min, which is equivalent to 23s (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). This corresponded to a sensitivity of 64% and a specificity of 69% with an AUC of 0.66 (95%CI 0.51–0.81; p=0.037).<elsevierMultimedia ident="fig0005"></elsevierMultimedia>The different MID estimations using distribution-based techniques are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. The MID ranged between a reduction of 0.38 and 1.05min in the time spent during the TGlittre.Subjects who achieved the MID of −0.38min for the TGlittre had a superior improvement of approximately 42 meters in the 6MWT when compared to patients who did not (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Furthermore, there was an association between achieving the MID in 6MWT and in TGlittre (Cramer's V=0.28; p=0.028).<elsevierMultimedia ident="fig0010"></elsevierMultimedia>At baseline, the ICC between the first and the second TGlittre was 0.95 (95%CI 0.92–0.97), with a learning effect of 7.6%. This learning effect reduced to 4.6% after the pulmonary rehabilitation, with an ICC of 0.98 (95%CI 0.96–0.99). The mean difference between Δ pre-rehabilitation and Δ post-rehabilitation was −0.20±0.70min (p=0.04).DiscussionThe present study established a MID of −0.38min (−0.38 to −1.05min) for the time spent in the TGlittre in patients with COPD after 24 sessions of pulmonary rehabilitation. Also, this MID proved to be able to differentiate patients regarding the 6MWT improvement.The variation of the MID values found by the different distribution methods is expected since the patients may present different magnitudes of improvement after a PRP. The MID is considered the minimum value necessary for clinical changes.<a class="elsevierStyleCrossRef" href="#bib0220">8</a> Therefore, it is recommended the use of the cut-off point of −0.38min, obtained by the standard error of measurement (SEM) method and the ROC curve. However, since more severe patients tend to show greater improvement after PRP,<a class="elsevierStyleCrossRef" href="#bib0335">31</a> the TGlittre's MID for them might be closer to −1.05min. The simultaneous use of distribution and anchor-based methods were used in the present study.<a class="elsevierStyleCrossRef" href="#bib0340">32</a> While distribution-based methods, such as the SEM, consider the psychometric and statistical properties of the instrument in the population of interest, the anchor-based method considers the change in other clinical relevant outcomes<a class="elsevierStyleCrossRefs" href="#bib0215">7,32</a> and recognizes the importance of improving the patient's clinical status, which should be considered when evaluating the effect of an intervention.<a class="elsevierStyleCrossRef" href="#bib0215">7</a>The results of this study, as in previous studies,<a class="elsevierStyleCrossRefs" href="#bib0230">10,16</a> showed a strong negative correlation between time spent on TGlittre and distance walked in 6MWT in patients with COPD (r=−0.78 to −0.87; p<0.05). It was expected to find similar results between the changes in the two tests after PRP. A possible explanation for the weak correlation found is that, despite evaluating the same functional status construct, TGlittre involves activities other than walking, that have not been specifically trained in PRP and that may induce limiting symptoms in different levels. A recent study from our group demonstrated that physiological responses differed among TGlittre's multiple tasks, and despite walking and moving objects on the shelf induced similar physiological responses, 63% of patients reported greater difficulty in performing the task of the shelf.<a class="elsevierStyleCrossRef" href="#bib0345">33</a> This task may involve squatting or bending over, that are not specifically trained in the PRP, beyond elevation of unsupported upper limbs. Although the upper limbs training included in our PRP protocol has been shown to be effective in improving their endurance,<a class="elsevierStyleCrossRef" href="#bib0350">34</a> its effect on the performance of ADLs are still contradictory.<a class="elsevierStyleCrossRefs" href="#bib0355">35,36</a> Therefore, although they measure the same construct of functional status and both instruments show responsiveness to pulmonary rehabilitation with similar effect sizes, TGlittre may be more specific than 6MWT to identify an improvement in the ability to perform ADLs other than walking. It may also explain why the AUC, sensitivity and specificity of the ROC curve were relatively low. Although there is no consensus in the literature regarding ideal sensitivity and specificity values, an AUC above 0.7 is considered acceptable.<a class="elsevierStyleCrossRef" href="#bib0330">30</a> In our study, we found an AUC slightly smaller. Thus, the cut-off point determined by the ROC curve may have low accuracy. However, it does not invalidate the MID found, since −0.38min was also the lowest value found by the distribution methods.Skumlien et al.<a class="elsevierStyleCrossRef" href="#bib0230">10</a> reported that TGlittre is responsive to PRP because the mean difference in the test after an intervention was higher than the learning effect found in the study (−0.89 95%CI −0.48 to −1.30 vs. −0.33min 95%CI −0.20 to −0.54). However, so far, no study had investigated the effect size of the TGlittre and whether the change in it after PRP was associated with a difference in similar outcomes. The present study demonstrated that TGlittre had an effect size similar to the 6MWT and that the value based on Cohen's d was high.<a class="elsevierStyleCrossRef" href="#bib0310">26</a> The reliability and learning effect of TGlittre had also been investigated in previous studies, which demonstrated results similar to ours (ICC 0.95–0.97; learning effect: 6.3–7.6%).<a class="elsevierStyleCrossRefs" href="#bib0230">10,12,13</a> Meanwhile, our study was the first to demonstrate that the learning effect of TGlittre after PRP was about 40% lower than the baseline learning effect. In other words, to perform only one test can overestimate the effects of PRP. Therefore, it is recommended to use the MID of −0.38min only in situations where TGlittre is applied twice.As far as we know, this is the first study to identify the MID for TGlittre in patients with COPD. The MID of TGlittre will allow the interpretation of the results after a PRP, supporting its use in clinical practice. Improving functional status is one of the main goals of pulmonary rehabilitation.<a class="elsevierStyleCrossRef" href="#bib0205">5</a> So, knowing the MID of TGlittre may help to identify whether or not the patients improved the ability to perform multiple ADLs after a PRP. In addition, the TGlittre MID may be used to determine the ‘number needed to treat’ in future intervention studies. Some limitations may be mentioned in this study. The use of an instrument that evaluates the perception of improvement by the patient as an anchor, which is widely recommended in the literature, could provide a MID that reflects changes in the patient's daily life. However, this perception is subjective and is not always associated with a change in objective measures. Thus, we have chosen an accurate, widely used and recommended functional capacity assessment tool. Another possible limitation is that the present study included patients with COPD from only two pulmonary rehabilitation centers, which may prevent the generalization of the results. However, we included patients with different degrees of disease severity (GOLD II-IV), which reflects the profile of patients normally included in studies from other centers.<a class="elsevierStyleCrossRef" href="#bib0205">5</a> Finally, although the MID of −0.38min was able to differentiate the change in functional capacity assessed by the 6MWT in the present sample, further studies are suggested to demonstrate the validity of this cutoff point in an independent sample.ConclusionsIn conclusion, the TGlittre is responsible for a PRP and its minimal important difference is −0.38min (−0.38 to −1.05min). It is recommended to use this minimal important difference only in situations where TGlittre is applied twice, since the learning effect of TGlittre after PRP was about 40% lower than the baseline learning effect. It is suggested that further studies are conducted to determine a TGlittre's minimal important difference for functional worsening.FundingThis research was supported in part by the Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior – CAPES/Brazil and the Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq/Brazil (Chamada Universal – MCTI/CNPq No. 14/2014) and the Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina – FAPESC/Brazil (PAP UDESC Chamada Publica No. 01/2016. Grant number 2017TR645).Conflicts of interestThe authors declare no conflicts of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1290633" "titulo" => "Highlights" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:3 [ "identificador" => "xres1290634" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] 2 => array:2 [ "identificador" => "xpalclavsec1192308" "titulo" => "Keywords" ] 3 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 4 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Subjects" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Study protocol" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Pulmonary rehabilitation program" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Statistical analysis" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Sample size" ] ] ] 5 => array:2 [ "identificador" => "sec0040" "titulo" => "Results" ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Conclusions" ] 8 => array:2 [ "identificador" => "sec0055" "titulo" => "Funding" ] 9 => array:2 [ "identificador" => "sec0060" "titulo" => "Conflicts of interest" ] 10 => array:2 [ "identificador" => "xack443716" "titulo" => "Acknowledgements" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-04-19" "fechaAceptado" => "2018-11-08" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1192308" "palabras" => array:6 [ 0 => "Pulmonary disease" 1 => "Chronic obstructive" 2 => "Rehabilitation" 3 => "Activities of daily living" 4 => "Exercise test" 5 => "Outcome assessment" ] ] ] ] "tieneResumen" => true "highlights" => array:2 [ "titulo" => "Highlights" "resumen" => "<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005">•Glittre-ADL test minimal important difference (MID) is −0.38min in COPD patients.</li><li class="elsevierStyleListItem" id="lsti0010">•Glittre-ADL test's MID reflects the changes in functional capacity.</li><li class="elsevierStyleListItem" id="lsti0015">•Two tests are necessary for interpretation of changes induced by pulmonary rehabilitation.</li></ul>" ] "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "ObjectiveTo determine Glittre-ADL test minimal important difference in patients with chronic obstructive pulmonary disease. MethodsThis is quasi-experimental study. Sixty patients with moderate to very severe chronic obstructive pulmonary disease (age 64.1, SD=9.09 years; forced expiratory volume in the first second 37.9, SD=13.0% predicted participated in a pulmonary rehabilitation program based on physical training, conducted over 24 sessions supervised, three times a week, including aerobic training in treadmill and resistance training for upper limbs and lower limbs. The main outcomes were the Glittre-ADL test and six-minute walk test, before and after 24 sessions of pulmonary rehabilitation. The minimal important difference was established using the distribution and anchor-based methods. ResultsPatients improved their functional capacity after the pulmonary rehabilitation. The effect sizes of Glittre-ADL test and six-minute walk test improvement were similar (0.45 vs 0.44, respectively). The established minimal important differences ranged from −0.38 to −1.05. The reduction of 0.38min (23s) corresponded to a sensitivity of 64% and a specificity of 69% with an area under the curve of 0.66 (95%CI 0.51–0.81; p=0.04). Subjects who achieved the minimal important difference of −0.38min for the Glittre-ADL test had a superior improvement of approximately 42m in the six-minute walk test when compared to patients who did not. ConclusionsThe present findings suggest −0.38min as the minimal important difference in the time spent in the Glittre-ADL test after 24 sessions of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease.Trial registration: NCT03251781 (https://clinicaltrials.gov/ct2/show/NCT03251781)" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1300 "Ancho" => 1317 "Tamanyo" => 39283 ] ] "descripcion" => array:1 [ "en" => "Receiver operating characteristic curves for change in Glittre-ADL test using the improvement of 30m in the six-minute walk test: AUC of 0.66 (95%CI 0.51–0.81; p=0.037), sensitivity of 64% and specificity of 69%." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1199 "Ancho" => 1322 "Tamanyo" => 74738 ] ] "descripcion" => array:1 [ "en" => "Comparison of the change in six-minute walk test (6MWT) between subjects who did and did not achieve minimal important difference (MID) for Glittre-ADL test (TGlittre)." ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "MID, minimal important difference; SEM, standard error of measurement; SD, standard deviation; sqrt, square root; ICC, intraclass correlation coeficiente; Δ, difference in Glittre ADL-test (end−baseline rehabilitation); baseline, time in Glittre ADL-test at baseline; MDC, minimal detectable change." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Method \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">MID calculation \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">MID (min) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">MID (s) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SEM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SDbaseline * sqrt (1−ICC) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Empirical rule effect size \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.08 * 6 * SDΔ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cohen's effect size \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5 * SDΔ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5 times SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5 * SDbaseline \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MDC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.96 * sqrt (2) * SEM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2210330.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Distribution-based estimates of the minimal important difference (MID) and results." ] ] 3 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "95%CI, 95% confidence interval; kg, kilograms; m, meters; BMI, body mass index; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; L, liter; %pred, percentage of predicted value. GOLD, spirometric classification of the Global Initiative for Chronic Obstructive Lung Disease." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean±SD \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95%CI \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">64.1±9.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61.8–66.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Smoking history, pack-years<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43.0 (37.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43.3–59.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Body weight, kg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70.2±15.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">66.4–74.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Height, m \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.65±0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.62–1.67 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI, kg/m2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.9±5.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.5–27.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEV1/FVC, L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.46±0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.44–0.49 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEV1, L<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.01 (1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.95–1.61 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEV1, %pred \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37.9±13.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34.5–41.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FVC, L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.37±0.77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.17–2.57 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FVC, %pred<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70.1 (24) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57.0–83.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GOLD II, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (20%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GOLD III, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31 (51.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GOLD IV, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (28.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2210328.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "Median (IQR)." ] ] ] "descripcion" => array:1 [ "en" => "Anthropometric characteristics and pulmonary function of the sample." ] ] 4 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "SD, standard deviation; Δ, post rehabilitation−pre-rehabilitation; TGlittre, Glittre-ADL test (Wilcoxon test); 6MWT, six-minute walk test (Student t test for paired samples); min, minute; m, meter." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="4" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Functional capacity improvement</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Effect size</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pre rehabilitation(mean±SD) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Post rehabilitation(mean±SD) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Δ \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cohen's d \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean difference/baseline SD \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TGlittre, min \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.42±1.69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.67±1.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.76±0.86 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.45 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6MWT, m \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">443±97.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">485±101 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42.4±.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.44 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2210329.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Functional capacity improvement." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:36 [ 0 => array:3 [ "identificador" => "bib0185" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "GOLD" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2018" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0190" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome measures in cardiopulmonary physical therapy: focus on the Glittre ADL-test for people with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. 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            "entidad" => "Physical Therapy Graduate Program&#44; Centro de Ci&#234;ncias da Sa&#250;de e do Esporte &#40;CEFID&#41;&#44; Universidade do Estado de Santa Catarina &#40;UDESC&#41;&#44; Florian&#243;polis&#44; SC&#44; Brazil"
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            "identificador" => "cor0005"
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            "correspondencia" => "Corresponding author at&#58; N&#250;cleo de Assist&#234;ncia&#44; Ensino e Pesquisa em Reabilita&#231;&#227;o Pulmonar&#44; UDESC&#44; Rua Pascoal Simone 358&#44; CEP 88080-350&#44; Florian&#243;polis&#44; SC&#44; Brazil&#46;"
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristic curves for change in Glittre-ADL test using the improvement of 30<span class="elsevierStyleHsp" style=""></span>m in the six-minute walk test&#58; AUC of 0&#46;66 &#40;95&#37;CI 0&#46;51&#8211;0&#46;81&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;037&#41;&#44; sensitivity of 64&#37; and specificity of 69&#37;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="par0020" class="elsevierStylePara elsevierViewall">Functional limitation is a common and important finding in patients with chronic obstructive pulmonary disease &#40;COPD&#41;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">1</span></a> which is directly related to a reduction in quality of life&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">2</span></a> a higher frequency of exacerbations and hospitalizations<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">3</span></a> and increased mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">4</span></a> Therefore&#44; it is an essential aspect of the evaluation routine of pulmonary rehabilitation programs &#40;PRP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Field tests are functional status assessment tools capable of objectively assessing patient performance in common daily tasks&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> There are numerous valid tests for patients with COPD&#44; and it is recommended to choose those with well-established measurement properties&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a> When the objective is to verify the effect of an intervention&#44; besides the choice of a responsive test&#44; it is necessary to know its minimal important difference &#40;MID&#41;&#44; which allows a better interpretation of the results obtained after the intervention&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a> The MID is defined as &#8220;a meaningful change or effect that might be considered important&#44; beneficial or harmful&#44; either by patients or informed proxies &#40;including clinicians&#41; and which would lead the patient&#47;clinician to consider a change in management&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">8</span></a> Among the most common functional capacity tests that present MID after PRP&#44; may be highlighted&#58; the six-minute walk test &#40;6MWT&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a> the Incremental Shuttle Walking Test<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a> and the five-repetition sit-to-stand test&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">However&#44; although other tests have well-established measurement properties and are gaining space regarding the functional capacity assessment of patients with COPD&#44; their MID has not been studied yet&#46; In this context&#44; there is the Glittre ADL-test &#40;TGlittre&#41;&#44; which is composed by multiple tasks common in daily life&#44; developed&#44; and validated specifically for patients with COPD&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;11</span></a> It is valid<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a> and reliable for assessing the functional capacity of clinically stable patients<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;12&#44;13</span></a> and hospitalized patients&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">14</span></a> TGlittre is responsive to PRP<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a> and it is able to differentiate the functional capacity of patients with COPD from healthy individuals&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">15</span></a> Also&#44; it correlates with several other instruments for assessing functional status<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;16&#8211;19</span></a> and health status<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">20</span></a> of patients with COPD&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Nevertheless&#44; the minimal change required in the TGlittre after an intervention to determine clinically important improvement is still not known&#46; Dechman and Scherer<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">2</span></a> suggest that it is approximately 1<span class="elsevierStyleHsp" style=""></span>min&#44; but it has not been formally tested and established&#46; Therefore&#44; the investigation of this response is relevant in order to evidence whether an intervention is capable of individually generating important changes in patient&#39;s capacity to perform multiple activities of daily living &#40;ADL&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">21</span></a> This would facilitate the interpretation of the test results after a PRP&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Therefore&#44; the aim of the current study was to determine TGlittre MID in patients with COPD&#46; Secondarily&#44; we aimed to analyze the reliability and to compare the learn effect of the time spent in TGlittre pre and post PRP&#44; as well as to investigate its responsivity after a PRP&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Subjects</span><p id="par0045" class="elsevierStylePara elsevierViewall">Patients with COPD &#40;GOLD II-IV&#41;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">1</span></a> were referred to PRP of the Center for Assistance&#44; Teaching and Research in Pulmonary Rehabilitation from the <span class="elsevierStyleItalic">Universidade do Estado de Santa Catarina</span> &#40;NuReab-UDESC&#41; and of the Research Group on Cardiopulmonary Interaction from the <span class="elsevierStyleItalic">Universidade Federal de Ci&#234;ncias da Sa&#250;de de Porto Alegre</span> &#40;GPIC-UFCSPA&#41;&#46; The inclusion criteria were&#58; clinical diagnosis of COPD confirmed by spirometry&#59; age of 40 years or more and clinical stability in the four weeks prior to the protocol&#46; Were excluded&#58; active smokers&#44; patients with any change in symptoms during the assessment protocol&#44; PRP interruption for any reason&#44; and patients with other respiratory&#44; cardiovascular&#44; neurological&#44; musculoskeletal and&#47;or rheumatologic diseases that could compromise the performance of the evaluations&#44; as well as the physical training established by the PRP&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">This study was approved by the Ethics Committee on Human Research at UDESC &#40;Florian&#243;polis&#44; Santa Catarina&#44; Brazil&#41;&#44; UFCSPA &#40;Porto Alegre&#44; Rio Grande do Sul&#44; Brazil&#41;&#44; and Irmandade da Santa Casa de Miseric&#243;rdia de Porto Alegre &#40;Porto Alegre&#44; Rio Grande do Sul&#44; Brazil&#41; &#40;CAAE 80831117&#46;5&#46;0000&#46;0118&#44; 1&#46;413&#46;342 and 836&#46;248&#44; respectively&#41; and all participants signed the consent form&#46; This study was registered and published in the Clinical Trials &#40;NCT03251781&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Study protocol</span><p id="par0055" class="elsevierStylePara elsevierViewall">Patients underwent pulmonary function assessment and&#44; on two separate days&#44; 6MWT and TGlittre&#46; Both functional capacity tests were performed before and after 24 training sessions&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The pulmonary function test was performed according to the recommendations and criteria of acceptability and reproducibility proposed by the American Thoracic Society&#47;European Respiratory Society&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">22</span></a> Spirometric measurements were obtained before and 15<span class="elsevierStyleHsp" style=""></span>min after the inhalation of 400<span class="elsevierStyleHsp" style=""></span>&#956;g of salbutamol&#46; The predicted values were calculated from the equation proposed for the Brazilian population&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">23</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The TGlittre was executed according to the protocol validated by Skumlien et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a> which consists of performing five laps in the shortest possible time in a standardized circuit arranged in a 10-m corridor&#44; carrying a backpack &#40;2&#46;5<span class="elsevierStyleHsp" style=""></span>kg for women and 5&#46;0<span class="elsevierStyleHsp" style=""></span>kg for men&#41;&#46; From the seated position&#44; the subject stands up and walks along a flat corridor&#44; in the middle of which there is a 3-step staircase &#40;each step 17<span class="elsevierStyleHsp" style=""></span>cm high<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>27<span class="elsevierStyleHsp" style=""></span>cm deep&#41; to be climbed&#46; At the end of the corridor&#44; the subject moves three 1-kg objects&#44; positioned on a shelf &#40;shoulders&#8217; height&#41;&#44; one by one&#44; to another shelf &#40;waist&#39;s height&#41; and then to the floor&#46; Then the objects are placed back on the lower shelf&#44; and finally returned to the upper shelf&#46; The subject returns&#44; in the reverse course&#44; to the initial sitting position&#46; Immediately after sitting down&#44; another lap must be started&#44; following the same circuit&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a> Two tests were performed&#44; with a minimum interval of 30<span class="elsevierStyleHsp" style=""></span>min or until the vital signs and symptoms returned to baseline&#46; The test performed in the shortest time was used for the analysis&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The 6MWT was used as an anchor and performed as recommended by the American Thoracic Society&#47;European Respiratory Society&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">24</span></a> Two tests were performed&#44; with a minimum interval of 30<span class="elsevierStyleHsp" style=""></span>min or until the signs and symptoms returned to baseline&#46; Before the test&#44; patients were instructed to travel as far as possible&#44; with standardized verbal encouragement every minute&#46; The best performance was considered for the analysis&#46; The MID of 30<span class="elsevierStyleHsp" style=""></span>m was considered as an anchor to determine the TGlittre&#39;s MID since it was established based on numerous studies&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Pulmonary rehabilitation program</span><p id="par0075" class="elsevierStylePara elsevierViewall">The PRP was designed according to the American Thoracic Society&#47;European Respiratory Society guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> The supervised physical training was conducted over 24 sessions&#44; three times a week&#46; The program included continuous aerobic training on treadmill &#40;30<span class="elsevierStyleHsp" style=""></span>min with training intensity determined by dyspnea sensation between 4 and 6 on the modified Borg scale&#41;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">25</span></a> and resistance training for upper limbs with free weights or elastic bands &#40;movements performed based on the modified diagonals of the proprioceptive neuromuscular facilitation method&#44; performed in two sets&#44; lasting 2<span class="elsevierStyleHsp" style=""></span>min each&#41; and lower limbs training &#40;quadriceps and triceps sural&#41; with free weights and&#47;or in the extensor chair &#40;2 sets of 10&#8211;15 repetitions&#41;&#46; Initially&#44; lower limbs were exercised with 2-kg and upper limbs were exercised without any external workload&#46; The localized training intensity was increased according to patient&#39;s perception of effort and difficulty &#40;easy or difficult&#41;&#46; If the exercise was &#8220;easy&#8221;&#44; the load was increased by 1<span class="elsevierStyleHsp" style=""></span>kg for lower and 0&#46;5<span class="elsevierStyleHsp" style=""></span>kg for upper limbs&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Statistical analysis</span><p id="par0080" class="elsevierStylePara elsevierViewall">The data analysis was performed in Statistical Package for Social Sciences &#40;SPSS&#41; 20&#46;0 and GraphPad Prism 5&#46; The Shapiro&#8211;Wilk test was used to verify the distribution of the data&#46; The Student&#39;s <span class="elsevierStyleItalic">T</span> for paired samples and Wilcoxon tests were used to compare the time spent in TGlittre and the distance in 6MWT before and after PRP&#46; The effect sizes of the change in TGlittre and 6MWT were calculated using Cohen&#39;s d statistics&#46; The following classification was considered&#58; small &#40;<span class="elsevierStyleItalic">d</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;2&#41;&#44; medium &#40;<span class="elsevierStyleItalic">d</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;5&#41; or large &#40;<span class="elsevierStyleItalic">d</span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>0&#46;8&#41; effect size&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">26</span></a> Intraclass correlation coefficient &#40;ICC&#41; was used to analyze the reliability of TGlittre &#40;ICC model&#58; &#8220;two-way random&#8221;&#59; ICC type&#58; &#8220;absolute agreement&#8221;&#41; and Student&#39;s <span class="elsevierStyleItalic">T</span> for paired samples or Wilcoxon tests were used to compare the learn effect of the time spent in TGlittre pre and post PRP&#46; The Spearman correlation coefficient was used to test the correlation between the change in TGlittre and the change in 6MWT and&#44; if there was a correlation &#8805;0&#46;3&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a> the MID of 30 meters for the 6MWT<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a> would be used as an anchor to determine the TGlittre&#39;s MID&#44; using the receiver operating characteristic &#40;ROC&#41; curve&#46; The distribution-based methods used to calculate TGlittre&#39;s MID are listed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">26&#8211;29</span></a> The Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span>-test was used to compare the change in distance walked in 6MWT between patients who achieved or not TGlittre&#39;s MID&#46; The association between achieve the TGlittre&#39;s MID &#40;yes&#47;no&#41; and achieve the 6MTWT&#39;s MID &#40;yes&#47;no&#41; was tested with Chi-square test followed by Cramer&#39;s <span class="elsevierStyleItalic">V</span> to demonstrate the magnitude of the association&#46; The significance level was 5&#37;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Sample size</span><p id="par0085" class="elsevierStylePara elsevierViewall">The sample size was calculated in MedCalc 17&#46;1&#44; aiming to achieve an area under the curve &#40;AUC&#41; of 0&#46;70&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">30</span></a> With a bidirectional <span class="elsevierStyleItalic">&#945;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05 and <span class="elsevierStyleItalic">&#946;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;20&#44; the estimated sample size was 60&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0090" class="elsevierStylePara elsevierViewall">From a total of 81 patients that engaged the study&#44; 60 &#40;37 men&#41; completed the PRP&#46; The reasons why 21 patients did not complete the PRP were&#58; death &#40;03&#41;&#59; started smoking &#40;01&#41;&#59; withdrawal &#40;07&#41;&#59; severe COPD exacerbation &#40;07&#41;&#59; cataract surgery &#40;02&#41;&#59; diverticulitis &#40;01&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows patients&#8217; baseline characteristics&#46; Subjects improved their functional capacity after the PRP &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#44; although 25 patients did not achieve the MID for the 6MWT &#40;improvement &#8805;30<span class="elsevierStyleHsp" style=""></span>m&#41;&#46; The effect sizes of TGlittre and 6MWT improvement were similar &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Patients who achieved the MID of 6MWT improved &#8722;0&#46;33<span class="elsevierStyleHsp" style=""></span>min &#40;95&#37;CI &#8722;0&#46;76 to &#8722;0&#46;08<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;038&#41; more in TGlittre when compared to those that did not achieve&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">The baseline TGlittre and 6MWT presented a negative correlation &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;78&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; and the change in the TGlittre correlated with the change in the 6MWT &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;31&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;015&#41;&#59; therefore&#44; it was used as the reliable anchor&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a> The ROC curve indicated a cutoff value for a clinically significant change in the TGlittre of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min&#44; which is equivalent to 23<span class="elsevierStyleHsp" style=""></span>s &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; This corresponded to a sensitivity of 64&#37; and a specificity of 69&#37; with an AUC of 0&#46;66 &#40;95&#37;CI 0&#46;51&#8211;0&#46;81&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;037&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">The different MID estimations using distribution-based techniques are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The MID ranged between a reduction of 0&#46;38 and 1&#46;05<span class="elsevierStyleHsp" style=""></span>min in the time spent during the TGlittre&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Subjects who achieved the MID of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min for the TGlittre had a superior improvement of approximately 42 meters in the 6MWT when compared to patients who did not &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Furthermore&#44; there was an association between achieving the MID in 6MWT and in TGlittre &#40;Cramer&#39;s <span class="elsevierStyleItalic">V</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;28&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;028&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">At baseline&#44; the ICC between the first and the second TGlittre was 0&#46;95 &#40;95&#37;CI 0&#46;92&#8211;0&#46;97&#41;&#44; with a learning effect of 7&#46;6&#37;&#46; This learning effect reduced to 4&#46;6&#37; after the pulmonary rehabilitation&#44; with an ICC of 0&#46;98 &#40;95&#37;CI 0&#46;96&#8211;0&#46;99&#41;&#46; The mean difference between &#916; pre-rehabilitation and &#916; post-rehabilitation was &#8722;0&#46;20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;70<span class="elsevierStyleHsp" style=""></span>min &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">The present study established a MID of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min &#40;&#8722;0&#46;38 to &#8722;1&#46;05<span class="elsevierStyleHsp" style=""></span>min&#41; for the time spent in the TGlittre in patients with COPD after 24 sessions of pulmonary rehabilitation&#46; Also&#44; this MID proved to be able to differentiate patients regarding the 6MWT improvement&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The variation of the MID values found by the different distribution methods is expected since the patients may present different magnitudes of improvement after a PRP&#46; The MID is considered the minimum value necessary for clinical changes&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">8</span></a> Therefore&#44; it is recommended the use of the cut-off point of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min&#44; obtained by the standard error of measurement &#40;SEM&#41; method and the ROC curve&#46; However&#44; since more severe patients tend to show greater improvement after PRP&#44;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">31</span></a> the TGlittre&#39;s MID for them might be closer to &#8722;1&#46;05<span class="elsevierStyleHsp" style=""></span>min&#46; The simultaneous use of distribution and anchor-based methods were used in the present study&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">32</span></a> While distribution-based methods&#44; such as the SEM&#44; consider the psychometric and statistical properties of the instrument in the population of interest&#44; the anchor-based method considers the change in other clinical relevant outcomes<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">7&#44;32</span></a> and recognizes the importance of improving the patient&#39;s clinical status&#44; which should be considered when evaluating the effect of an intervention&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">The results of this study&#44; as in previous studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;16</span></a> showed a strong negative correlation between time spent on TGlittre and distance walked in 6MWT in patients with COPD &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;78 to &#8722;0&#46;87&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; It was expected to find similar results between the changes in the two tests after PRP&#46; A possible explanation for the weak correlation found is that&#44; despite evaluating the same functional status construct&#44; TGlittre involves activities other than walking&#44; that have not been specifically trained in PRP and that may induce limiting symptoms in different levels&#46; A recent study from our group demonstrated that physiological responses differed among TGlittre&#39;s multiple tasks&#44; and despite walking and moving objects on the shelf induced similar physiological responses&#44; 63&#37; of patients reported greater difficulty in performing the task of the shelf&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">33</span></a> This task may involve squatting or bending over&#44; that are not specifically trained in the PRP&#44; beyond elevation of unsupported upper limbs&#46; Although the upper limbs training included in our PRP protocol has been shown to be effective in improving their endurance&#44;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">34</span></a> its effect on the performance of ADLs are still contradictory&#46;<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">35&#44;36</span></a> Therefore&#44; although they measure the same construct of functional status and both instruments show responsiveness to pulmonary rehabilitation with similar effect sizes&#44; TGlittre may be more specific than 6MWT to identify an improvement in the ability to perform ADLs other than walking&#46; It may also explain why the AUC&#44; sensitivity and specificity of the ROC curve were relatively low&#46; Although there is no consensus in the literature regarding ideal sensitivity and specificity values&#44; an AUC above 0&#46;7 is considered acceptable&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">30</span></a> In our study&#44; we found an AUC slightly smaller&#46; Thus&#44; the cut-off point determined by the ROC curve may have low accuracy&#46; However&#44; it does not invalidate the MID found&#44; since &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min was also the lowest value found by the distribution methods&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Skumlien et al&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a> reported that TGlittre is responsive to PRP because the mean difference in the test after an intervention was higher than the learning effect found in the study &#40;&#8722;0&#46;89 95&#37;CI &#8722;0&#46;48 to &#8722;1&#46;30 <span class="elsevierStyleItalic">vs&#46;</span> &#8722;0&#46;33<span class="elsevierStyleHsp" style=""></span>min 95&#37;CI &#8722;0&#46;20 to &#8722;0&#46;54&#41;&#46; However&#44; so far&#44; no study had investigated the effect size of the TGlittre and whether the change in it after PRP was associated with a difference in similar outcomes&#46; The present study demonstrated that TGlittre had an effect size similar to the 6MWT and that the value based on Cohen&#39;s d was high&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">26</span></a> The reliability and learning effect of TGlittre had also been investigated in previous studies&#44; which demonstrated results similar to ours &#40;ICC 0&#46;95&#8211;0&#46;97&#59; learning effect&#58; 6&#46;3&#8211;7&#46;6&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;12&#44;13</span></a> Meanwhile&#44; our study was the first to demonstrate that the learning effect of TGlittre after PRP was about 40&#37; lower than the baseline learning effect&#46; In other words&#44; to perform only one test can overestimate the effects of PRP&#46; Therefore&#44; it is recommended to use the MID of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min only in situations where TGlittre is applied twice&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">As far as we know&#44; this is the first study to identify the MID for TGlittre in patients with COPD&#46; The MID of TGlittre will allow the interpretation of the results after a PRP&#44; supporting its use in clinical practice&#46; Improving functional status is one of the main goals of pulmonary rehabilitation&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> So&#44; knowing the MID of TGlittre may help to identify whether or not the patients improved the ability to perform multiple ADLs after a PRP&#46; In addition&#44; the TGlittre MID may be used to determine the &#8216;number needed to treat&#8217; in future intervention studies&#46; Some limitations may be mentioned in this study&#46; The use of an instrument that evaluates the perception of improvement by the patient as an anchor&#44; which is widely recommended in the literature&#44; could provide a MID that reflects changes in the patient&#39;s daily life&#46; However&#44; this perception is subjective and is not always associated with a change in objective measures&#46; Thus&#44; we have chosen an accurate&#44; widely used and recommended functional capacity assessment tool&#46; Another possible limitation is that the present study included patients with COPD from only two pulmonary rehabilitation centers&#44; which may prevent the generalization of the results&#46; However&#44; we included patients with different degrees of disease severity &#40;GOLD II-IV&#41;&#44; which reflects the profile of patients normally included in studies from other centers&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> Finally&#44; although the MID of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min was able to differentiate the change in functional capacity assessed by the 6MWT in the present sample&#44; further studies are suggested to demonstrate the validity of this cutoff point in an independent sample&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusions</span><p id="par0140" class="elsevierStylePara elsevierViewall">In conclusion&#44; the TGlittre is responsible for a PRP and its minimal important difference is &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min &#40;&#8722;0&#46;38 to &#8722;1&#46;05<span class="elsevierStyleHsp" style=""></span>min&#41;&#46; It is recommended to use this minimal important difference only in situations where TGlittre is applied twice&#44; since the learning effect of TGlittre after PRP was about 40&#37; lower than the baseline learning effect&#46; It is suggested that further studies are conducted to determine a TGlittre&#39;s minimal important difference for functional worsening&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Funding</span><p id="par0145" class="elsevierStylePara elsevierViewall">This research was supported in part by the Coordena&#231;&#227;o de Aperfei&#231;oamento de Pessoal de Ensino Superior &#8211; CAPES&#47;Brazil and the Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#8211; CNPq&#47;Brazil &#40;Chamada Universal &#8211; MCTI&#47;CNPq No&#46; 14&#47;2014&#41; and the Funda&#231;&#227;o de Amparo &#224; Pesquisa e Inova&#231;&#227;o do Estado de Santa Catarina &#8211; FAPESC&#47;Brazil &#40;PAP UDESC Chamada Publica No&#46; 01&#47;2016&#46; Grant number 2017TR645&#41;&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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    "fechaRecibido" => "2018-04-19"
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          "clase" => "keyword"
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            0 => "Pulmonary disease"
            1 => "Chronic obstructive"
            2 => "Rehabilitation"
            3 => "Activities of daily living"
            4 => "Exercise test"
            5 => "Outcome assessment"
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    "highlights" => array:2 [
      "titulo" => "Highlights"
      "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0005" class="elsevierStylePara elsevierViewall">Glittre-ADL test minimal important difference &#40;MID&#41; is &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min in COPD patients&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0010" class="elsevierStylePara elsevierViewall">Glittre-ADL test&#39;s MID reflects the changes in functional capacity&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0015" class="elsevierStylePara elsevierViewall">Two tests are necessary for interpretation of changes induced by pulmonary rehabilitation&#46;</p></li></ul></p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine Glittre-ADL test minimal important difference in patients with chronic obstructive pulmonary disease&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">This is quasi-experimental study&#46; Sixty patients with moderate to very severe chronic obstructive pulmonary disease &#40;age 64&#46;1&#44; SD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#46;09 years&#59; forced expiratory volume in the first second 37&#46;9&#44; SD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#46;0&#37; predicted participated in a pulmonary rehabilitation program based on physical training&#44; conducted over 24 sessions supervised&#44; three times a week&#44; including aerobic training in treadmill and resistance training for upper limbs and lower limbs&#46; The main outcomes were the Glittre-ADL test and six-minute walk test&#44; before and after 24 sessions of pulmonary rehabilitation&#46; The minimal important difference was established using the distribution and anchor-based methods&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Patients improved their functional capacity after the pulmonary rehabilitation&#46; The effect sizes of Glittre-ADL test and six-minute walk test improvement were similar &#40;0&#46;45 <span class="elsevierStyleItalic">vs</span> 0&#46;44&#44; respectively&#41;&#46; The established minimal important differences ranged from &#8722;0&#46;38 to &#8722;1&#46;05&#46; The reduction of 0&#46;38<span class="elsevierStyleHsp" style=""></span>min &#40;23<span class="elsevierStyleHsp" style=""></span>s&#41; corresponded to a sensitivity of 64&#37; and a specificity of 69&#37; with an area under the curve of 0&#46;66 &#40;95&#37;CI 0&#46;51&#8211;0&#46;81&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46; Subjects who achieved the minimal important difference of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min for the Glittre-ADL test had a superior improvement of approximately 42<span class="elsevierStyleHsp" style=""></span>m in the six-minute walk test when compared to patients who did not&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The present findings suggest &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min as the minimal important difference in the time spent in the Glittre-ADL test after 24 sessions of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Trial registration&#58; NCT03251781 &#40;<span class="elsevierStyleInterRef" id="intr0005" href="https://clinicaltrials.gov/ct2/show/NCT03251781">https&#58;&#47;&#47;clinicaltrials&#46;gov&#47;ct2&#47;show&#47;NCT03251781</span>&#41;</p></span>"
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristic curves for change in Glittre-ADL test using the improvement of 30<span class="elsevierStyleHsp" style=""></span>m in the six-minute walk test&#58; AUC of 0&#46;66 &#40;95&#37;CI 0&#46;51&#8211;0&#46;81&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;037&#41;&#44; sensitivity of 64&#37; and specificity of 69&#37;&#46;</p>"
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                  \t\t\t\t">22&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5 times SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5 &#42; SD<span class="elsevierStyleInf">baseline</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#8722;0&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">50&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">MDC&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;96 &#42; sqrt &#40;2&#41; &#42; SEM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;1&#46;05&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">63&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">95&#37;CI&#44; 95&#37; confidence interval&#59; kg&#44; kilograms&#59; m&#44; meters&#59; BMI&#44; body mass index&#59; FEV<span class="elsevierStyleInf">1</span>&#44; forced expiratory volume in one second&#59; FVC&#44; forced vital capacity&#59; L&#44; liter&#59; &#37;pred&#44; percentage of predicted value&#46; GOLD&#44; spirometric classification of the Global Initiative for Chronic Obstructive Lung Disease&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
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                  \t\t\t\t">Age&#44; years&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">64&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">61&#46;8&#8211;66&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Smoking history&#44; pack-years<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">43&#46;0 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#46;3&#8211;59&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Body weight&#44; kg&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">70&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">66&#46;4&#8211;74&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Height&#44; m&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;09&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;62&#8211;1&#46;67&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;5&#8211;27&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FEV<span class="elsevierStyleInf">1</span>&#47;FVC&#44; L&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;46<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;44&#8211;0&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">FEV<span class="elsevierStyleInf">1</span>&#44; L<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;01 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;95&#8211;1&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">FEV<span class="elsevierStyleInf">1</span>&#44; &#37;pred&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#46;5&#8211;41&#46;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FVC&#44; L&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2&#46;17&#8211;2&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FVC&#44; &#37;pred<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#46;1 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">57&#46;0&#8211;83&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GOLD II&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;20&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GOLD III&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">31 &#40;51&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">GOLD IV&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;28&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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Statistics

Original Research

The minimal important difference for Glittre-ADL test in patients with chronic obstructive pulmonary disease

Aline Almeida Gularta,b, Cintia Laura Pereira de Araujoc,d, Anelise Bauer Munaria,b, Karoliny dos Santosa, Manuela Karloha,e, Betina Gabriele Foscarinic, Pedro Dal Lagoc,d, Anamaria Fleig Mayera,b,e,

Corresponding author

anamaria.mayer@udesc.br

Corresponding author at: Núcleo de Assistência, Ensino e Pesquisa em Reabilitação Pulmonar, UDESC, Rua Pascoal Simone 358, CEP 88080-350, Florianópolis, SC, Brazil.

a Center for Assistance, Teaching and Research in Pulmonary Rehabilitation (NuReab), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil

b Human Movement Sciences Graduate Program, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil

c Research Group on Cardiopulmonary Interaction (GPIC), Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil

d Health Sciences Graduate Program, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil

e Physical Therapy Graduate Program, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil

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            "entidad" => "Physical Therapy Graduate Program&#44; Centro de Ci&#234;ncias da Sa&#250;de e do Esporte &#40;CEFID&#41;&#44; Universidade do Estado de Santa Catarina &#40;UDESC&#41;&#44; Florian&#243;polis&#44; SC&#44; Brazil"
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            "identificador" => "cor0005"
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            "correspondencia" => "Corresponding author at&#58; N&#250;cleo de Assist&#234;ncia&#44; Ensino e Pesquisa em Reabilita&#231;&#227;o Pulmonar&#44; UDESC&#44; Rua Pascoal Simone 358&#44; CEP 88080-350&#44; Florian&#243;polis&#44; SC&#44; Brazil&#46;"
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristic curves for change in Glittre-ADL test using the improvement of 30<span class="elsevierStyleHsp" style=""></span>m in the six-minute walk test&#58; AUC of 0&#46;66 &#40;95&#37;CI 0&#46;51&#8211;0&#46;81&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;037&#41;&#44; sensitivity of 64&#37; and specificity of 69&#37;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="par0020" class="elsevierStylePara elsevierViewall">Functional limitation is a common and important finding in patients with chronic obstructive pulmonary disease &#40;COPD&#41;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">1</span></a> which is directly related to a reduction in quality of life&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">2</span></a> a higher frequency of exacerbations and hospitalizations<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">3</span></a> and increased mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">4</span></a> Therefore&#44; it is an essential aspect of the evaluation routine of pulmonary rehabilitation programs &#40;PRP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Field tests are functional status assessment tools capable of objectively assessing patient performance in common daily tasks&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> There are numerous valid tests for patients with COPD&#44; and it is recommended to choose those with well-established measurement properties&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a> When the objective is to verify the effect of an intervention&#44; besides the choice of a responsive test&#44; it is necessary to know its minimal important difference &#40;MID&#41;&#44; which allows a better interpretation of the results obtained after the intervention&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a> The MID is defined as &#8220;a meaningful change or effect that might be considered important&#44; beneficial or harmful&#44; either by patients or informed proxies &#40;including clinicians&#41; and which would lead the patient&#47;clinician to consider a change in management&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">8</span></a> Among the most common functional capacity tests that present MID after PRP&#44; may be highlighted&#58; the six-minute walk test &#40;6MWT&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a> the Incremental Shuttle Walking Test<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a> and the five-repetition sit-to-stand test&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">However&#44; although other tests have well-established measurement properties and are gaining space regarding the functional capacity assessment of patients with COPD&#44; their MID has not been studied yet&#46; In this context&#44; there is the Glittre ADL-test &#40;TGlittre&#41;&#44; which is composed by multiple tasks common in daily life&#44; developed&#44; and validated specifically for patients with COPD&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;11</span></a> It is valid<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a> and reliable for assessing the functional capacity of clinically stable patients<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;12&#44;13</span></a> and hospitalized patients&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">14</span></a> TGlittre is responsive to PRP<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a> and it is able to differentiate the functional capacity of patients with COPD from healthy individuals&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">15</span></a> Also&#44; it correlates with several other instruments for assessing functional status<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;16&#8211;19</span></a> and health status<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">20</span></a> of patients with COPD&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Nevertheless&#44; the minimal change required in the TGlittre after an intervention to determine clinically important improvement is still not known&#46; Dechman and Scherer<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">2</span></a> suggest that it is approximately 1<span class="elsevierStyleHsp" style=""></span>min&#44; but it has not been formally tested and established&#46; Therefore&#44; the investigation of this response is relevant in order to evidence whether an intervention is capable of individually generating important changes in patient&#39;s capacity to perform multiple activities of daily living &#40;ADL&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">21</span></a> This would facilitate the interpretation of the test results after a PRP&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Therefore&#44; the aim of the current study was to determine TGlittre MID in patients with COPD&#46; Secondarily&#44; we aimed to analyze the reliability and to compare the learn effect of the time spent in TGlittre pre and post PRP&#44; as well as to investigate its responsivity after a PRP&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Subjects</span><p id="par0045" class="elsevierStylePara elsevierViewall">Patients with COPD &#40;GOLD II-IV&#41;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">1</span></a> were referred to PRP of the Center for Assistance&#44; Teaching and Research in Pulmonary Rehabilitation from the <span class="elsevierStyleItalic">Universidade do Estado de Santa Catarina</span> &#40;NuReab-UDESC&#41; and of the Research Group on Cardiopulmonary Interaction from the <span class="elsevierStyleItalic">Universidade Federal de Ci&#234;ncias da Sa&#250;de de Porto Alegre</span> &#40;GPIC-UFCSPA&#41;&#46; The inclusion criteria were&#58; clinical diagnosis of COPD confirmed by spirometry&#59; age of 40 years or more and clinical stability in the four weeks prior to the protocol&#46; Were excluded&#58; active smokers&#44; patients with any change in symptoms during the assessment protocol&#44; PRP interruption for any reason&#44; and patients with other respiratory&#44; cardiovascular&#44; neurological&#44; musculoskeletal and&#47;or rheumatologic diseases that could compromise the performance of the evaluations&#44; as well as the physical training established by the PRP&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">This study was approved by the Ethics Committee on Human Research at UDESC &#40;Florian&#243;polis&#44; Santa Catarina&#44; Brazil&#41;&#44; UFCSPA &#40;Porto Alegre&#44; Rio Grande do Sul&#44; Brazil&#41;&#44; and Irmandade da Santa Casa de Miseric&#243;rdia de Porto Alegre &#40;Porto Alegre&#44; Rio Grande do Sul&#44; Brazil&#41; &#40;CAAE 80831117&#46;5&#46;0000&#46;0118&#44; 1&#46;413&#46;342 and 836&#46;248&#44; respectively&#41; and all participants signed the consent form&#46; This study was registered and published in the Clinical Trials &#40;NCT03251781&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Study protocol</span><p id="par0055" class="elsevierStylePara elsevierViewall">Patients underwent pulmonary function assessment and&#44; on two separate days&#44; 6MWT and TGlittre&#46; Both functional capacity tests were performed before and after 24 training sessions&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The pulmonary function test was performed according to the recommendations and criteria of acceptability and reproducibility proposed by the American Thoracic Society&#47;European Respiratory Society&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">22</span></a> Spirometric measurements were obtained before and 15<span class="elsevierStyleHsp" style=""></span>min after the inhalation of 400<span class="elsevierStyleHsp" style=""></span>&#956;g of salbutamol&#46; The predicted values were calculated from the equation proposed for the Brazilian population&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">23</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The TGlittre was executed according to the protocol validated by Skumlien et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a> which consists of performing five laps in the shortest possible time in a standardized circuit arranged in a 10-m corridor&#44; carrying a backpack &#40;2&#46;5<span class="elsevierStyleHsp" style=""></span>kg for women and 5&#46;0<span class="elsevierStyleHsp" style=""></span>kg for men&#41;&#46; From the seated position&#44; the subject stands up and walks along a flat corridor&#44; in the middle of which there is a 3-step staircase &#40;each step 17<span class="elsevierStyleHsp" style=""></span>cm high<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>27<span class="elsevierStyleHsp" style=""></span>cm deep&#41; to be climbed&#46; At the end of the corridor&#44; the subject moves three 1-kg objects&#44; positioned on a shelf &#40;shoulders&#8217; height&#41;&#44; one by one&#44; to another shelf &#40;waist&#39;s height&#41; and then to the floor&#46; Then the objects are placed back on the lower shelf&#44; and finally returned to the upper shelf&#46; The subject returns&#44; in the reverse course&#44; to the initial sitting position&#46; Immediately after sitting down&#44; another lap must be started&#44; following the same circuit&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a> Two tests were performed&#44; with a minimum interval of 30<span class="elsevierStyleHsp" style=""></span>min or until the vital signs and symptoms returned to baseline&#46; The test performed in the shortest time was used for the analysis&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The 6MWT was used as an anchor and performed as recommended by the American Thoracic Society&#47;European Respiratory Society&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">24</span></a> Two tests were performed&#44; with a minimum interval of 30<span class="elsevierStyleHsp" style=""></span>min or until the signs and symptoms returned to baseline&#46; Before the test&#44; patients were instructed to travel as far as possible&#44; with standardized verbal encouragement every minute&#46; The best performance was considered for the analysis&#46; The MID of 30<span class="elsevierStyleHsp" style=""></span>m was considered as an anchor to determine the TGlittre&#39;s MID since it was established based on numerous studies&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Pulmonary rehabilitation program</span><p id="par0075" class="elsevierStylePara elsevierViewall">The PRP was designed according to the American Thoracic Society&#47;European Respiratory Society guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> The supervised physical training was conducted over 24 sessions&#44; three times a week&#46; The program included continuous aerobic training on treadmill &#40;30<span class="elsevierStyleHsp" style=""></span>min with training intensity determined by dyspnea sensation between 4 and 6 on the modified Borg scale&#41;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">25</span></a> and resistance training for upper limbs with free weights or elastic bands &#40;movements performed based on the modified diagonals of the proprioceptive neuromuscular facilitation method&#44; performed in two sets&#44; lasting 2<span class="elsevierStyleHsp" style=""></span>min each&#41; and lower limbs training &#40;quadriceps and triceps sural&#41; with free weights and&#47;or in the extensor chair &#40;2 sets of 10&#8211;15 repetitions&#41;&#46; Initially&#44; lower limbs were exercised with 2-kg and upper limbs were exercised without any external workload&#46; The localized training intensity was increased according to patient&#39;s perception of effort and difficulty &#40;easy or difficult&#41;&#46; If the exercise was &#8220;easy&#8221;&#44; the load was increased by 1<span class="elsevierStyleHsp" style=""></span>kg for lower and 0&#46;5<span class="elsevierStyleHsp" style=""></span>kg for upper limbs&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Statistical analysis</span><p id="par0080" class="elsevierStylePara elsevierViewall">The data analysis was performed in Statistical Package for Social Sciences &#40;SPSS&#41; 20&#46;0 and GraphPad Prism 5&#46; The Shapiro&#8211;Wilk test was used to verify the distribution of the data&#46; The Student&#39;s <span class="elsevierStyleItalic">T</span> for paired samples and Wilcoxon tests were used to compare the time spent in TGlittre and the distance in 6MWT before and after PRP&#46; The effect sizes of the change in TGlittre and 6MWT were calculated using Cohen&#39;s d statistics&#46; The following classification was considered&#58; small &#40;<span class="elsevierStyleItalic">d</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;2&#41;&#44; medium &#40;<span class="elsevierStyleItalic">d</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;5&#41; or large &#40;<span class="elsevierStyleItalic">d</span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>0&#46;8&#41; effect size&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">26</span></a> Intraclass correlation coefficient &#40;ICC&#41; was used to analyze the reliability of TGlittre &#40;ICC model&#58; &#8220;two-way random&#8221;&#59; ICC type&#58; &#8220;absolute agreement&#8221;&#41; and Student&#39;s <span class="elsevierStyleItalic">T</span> for paired samples or Wilcoxon tests were used to compare the learn effect of the time spent in TGlittre pre and post PRP&#46; The Spearman correlation coefficient was used to test the correlation between the change in TGlittre and the change in 6MWT and&#44; if there was a correlation &#8805;0&#46;3&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a> the MID of 30 meters for the 6MWT<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">6</span></a> would be used as an anchor to determine the TGlittre&#39;s MID&#44; using the receiver operating characteristic &#40;ROC&#41; curve&#46; The distribution-based methods used to calculate TGlittre&#39;s MID are listed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">26&#8211;29</span></a> The Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span>-test was used to compare the change in distance walked in 6MWT between patients who achieved or not TGlittre&#39;s MID&#46; The association between achieve the TGlittre&#39;s MID &#40;yes&#47;no&#41; and achieve the 6MTWT&#39;s MID &#40;yes&#47;no&#41; was tested with Chi-square test followed by Cramer&#39;s <span class="elsevierStyleItalic">V</span> to demonstrate the magnitude of the association&#46; The significance level was 5&#37;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Sample size</span><p id="par0085" class="elsevierStylePara elsevierViewall">The sample size was calculated in MedCalc 17&#46;1&#44; aiming to achieve an area under the curve &#40;AUC&#41; of 0&#46;70&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">30</span></a> With a bidirectional <span class="elsevierStyleItalic">&#945;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05 and <span class="elsevierStyleItalic">&#946;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;20&#44; the estimated sample size was 60&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0090" class="elsevierStylePara elsevierViewall">From a total of 81 patients that engaged the study&#44; 60 &#40;37 men&#41; completed the PRP&#46; The reasons why 21 patients did not complete the PRP were&#58; death &#40;03&#41;&#59; started smoking &#40;01&#41;&#59; withdrawal &#40;07&#41;&#59; severe COPD exacerbation &#40;07&#41;&#59; cataract surgery &#40;02&#41;&#59; diverticulitis &#40;01&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows patients&#8217; baseline characteristics&#46; Subjects improved their functional capacity after the PRP &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#44; although 25 patients did not achieve the MID for the 6MWT &#40;improvement &#8805;30<span class="elsevierStyleHsp" style=""></span>m&#41;&#46; The effect sizes of TGlittre and 6MWT improvement were similar &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Patients who achieved the MID of 6MWT improved &#8722;0&#46;33<span class="elsevierStyleHsp" style=""></span>min &#40;95&#37;CI &#8722;0&#46;76 to &#8722;0&#46;08<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;038&#41; more in TGlittre when compared to those that did not achieve&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">The baseline TGlittre and 6MWT presented a negative correlation &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;78&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; and the change in the TGlittre correlated with the change in the 6MWT &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;31&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;015&#41;&#59; therefore&#44; it was used as the reliable anchor&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a> The ROC curve indicated a cutoff value for a clinically significant change in the TGlittre of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min&#44; which is equivalent to 23<span class="elsevierStyleHsp" style=""></span>s &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; This corresponded to a sensitivity of 64&#37; and a specificity of 69&#37; with an AUC of 0&#46;66 &#40;95&#37;CI 0&#46;51&#8211;0&#46;81&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;037&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">The different MID estimations using distribution-based techniques are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The MID ranged between a reduction of 0&#46;38 and 1&#46;05<span class="elsevierStyleHsp" style=""></span>min in the time spent during the TGlittre&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Subjects who achieved the MID of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min for the TGlittre had a superior improvement of approximately 42 meters in the 6MWT when compared to patients who did not &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Furthermore&#44; there was an association between achieving the MID in 6MWT and in TGlittre &#40;Cramer&#39;s <span class="elsevierStyleItalic">V</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;28&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;028&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">At baseline&#44; the ICC between the first and the second TGlittre was 0&#46;95 &#40;95&#37;CI 0&#46;92&#8211;0&#46;97&#41;&#44; with a learning effect of 7&#46;6&#37;&#46; This learning effect reduced to 4&#46;6&#37; after the pulmonary rehabilitation&#44; with an ICC of 0&#46;98 &#40;95&#37;CI 0&#46;96&#8211;0&#46;99&#41;&#46; The mean difference between &#916; pre-rehabilitation and &#916; post-rehabilitation was &#8722;0&#46;20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;70<span class="elsevierStyleHsp" style=""></span>min &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">The present study established a MID of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min &#40;&#8722;0&#46;38 to &#8722;1&#46;05<span class="elsevierStyleHsp" style=""></span>min&#41; for the time spent in the TGlittre in patients with COPD after 24 sessions of pulmonary rehabilitation&#46; Also&#44; this MID proved to be able to differentiate patients regarding the 6MWT improvement&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The variation of the MID values found by the different distribution methods is expected since the patients may present different magnitudes of improvement after a PRP&#46; The MID is considered the minimum value necessary for clinical changes&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">8</span></a> Therefore&#44; it is recommended the use of the cut-off point of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min&#44; obtained by the standard error of measurement &#40;SEM&#41; method and the ROC curve&#46; However&#44; since more severe patients tend to show greater improvement after PRP&#44;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">31</span></a> the TGlittre&#39;s MID for them might be closer to &#8722;1&#46;05<span class="elsevierStyleHsp" style=""></span>min&#46; The simultaneous use of distribution and anchor-based methods were used in the present study&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">32</span></a> While distribution-based methods&#44; such as the SEM&#44; consider the psychometric and statistical properties of the instrument in the population of interest&#44; the anchor-based method considers the change in other clinical relevant outcomes<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">7&#44;32</span></a> and recognizes the importance of improving the patient&#39;s clinical status&#44; which should be considered when evaluating the effect of an intervention&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">The results of this study&#44; as in previous studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;16</span></a> showed a strong negative correlation between time spent on TGlittre and distance walked in 6MWT in patients with COPD &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;78 to &#8722;0&#46;87&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; It was expected to find similar results between the changes in the two tests after PRP&#46; A possible explanation for the weak correlation found is that&#44; despite evaluating the same functional status construct&#44; TGlittre involves activities other than walking&#44; that have not been specifically trained in PRP and that may induce limiting symptoms in different levels&#46; A recent study from our group demonstrated that physiological responses differed among TGlittre&#39;s multiple tasks&#44; and despite walking and moving objects on the shelf induced similar physiological responses&#44; 63&#37; of patients reported greater difficulty in performing the task of the shelf&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">33</span></a> This task may involve squatting or bending over&#44; that are not specifically trained in the PRP&#44; beyond elevation of unsupported upper limbs&#46; Although the upper limbs training included in our PRP protocol has been shown to be effective in improving their endurance&#44;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">34</span></a> its effect on the performance of ADLs are still contradictory&#46;<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">35&#44;36</span></a> Therefore&#44; although they measure the same construct of functional status and both instruments show responsiveness to pulmonary rehabilitation with similar effect sizes&#44; TGlittre may be more specific than 6MWT to identify an improvement in the ability to perform ADLs other than walking&#46; It may also explain why the AUC&#44; sensitivity and specificity of the ROC curve were relatively low&#46; Although there is no consensus in the literature regarding ideal sensitivity and specificity values&#44; an AUC above 0&#46;7 is considered acceptable&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">30</span></a> In our study&#44; we found an AUC slightly smaller&#46; Thus&#44; the cut-off point determined by the ROC curve may have low accuracy&#46; However&#44; it does not invalidate the MID found&#44; since &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min was also the lowest value found by the distribution methods&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Skumlien et al&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">10</span></a> reported that TGlittre is responsive to PRP because the mean difference in the test after an intervention was higher than the learning effect found in the study &#40;&#8722;0&#46;89 95&#37;CI &#8722;0&#46;48 to &#8722;1&#46;30 <span class="elsevierStyleItalic">vs&#46;</span> &#8722;0&#46;33<span class="elsevierStyleHsp" style=""></span>min 95&#37;CI &#8722;0&#46;20 to &#8722;0&#46;54&#41;&#46; However&#44; so far&#44; no study had investigated the effect size of the TGlittre and whether the change in it after PRP was associated with a difference in similar outcomes&#46; The present study demonstrated that TGlittre had an effect size similar to the 6MWT and that the value based on Cohen&#39;s d was high&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">26</span></a> The reliability and learning effect of TGlittre had also been investigated in previous studies&#44; which demonstrated results similar to ours &#40;ICC 0&#46;95&#8211;0&#46;97&#59; learning effect&#58; 6&#46;3&#8211;7&#46;6&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">10&#44;12&#44;13</span></a> Meanwhile&#44; our study was the first to demonstrate that the learning effect of TGlittre after PRP was about 40&#37; lower than the baseline learning effect&#46; In other words&#44; to perform only one test can overestimate the effects of PRP&#46; Therefore&#44; it is recommended to use the MID of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min only in situations where TGlittre is applied twice&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">As far as we know&#44; this is the first study to identify the MID for TGlittre in patients with COPD&#46; The MID of TGlittre will allow the interpretation of the results after a PRP&#44; supporting its use in clinical practice&#46; Improving functional status is one of the main goals of pulmonary rehabilitation&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> So&#44; knowing the MID of TGlittre may help to identify whether or not the patients improved the ability to perform multiple ADLs after a PRP&#46; In addition&#44; the TGlittre MID may be used to determine the &#8216;number needed to treat&#8217; in future intervention studies&#46; Some limitations may be mentioned in this study&#46; The use of an instrument that evaluates the perception of improvement by the patient as an anchor&#44; which is widely recommended in the literature&#44; could provide a MID that reflects changes in the patient&#39;s daily life&#46; However&#44; this perception is subjective and is not always associated with a change in objective measures&#46; Thus&#44; we have chosen an accurate&#44; widely used and recommended functional capacity assessment tool&#46; Another possible limitation is that the present study included patients with COPD from only two pulmonary rehabilitation centers&#44; which may prevent the generalization of the results&#46; However&#44; we included patients with different degrees of disease severity &#40;GOLD II-IV&#41;&#44; which reflects the profile of patients normally included in studies from other centers&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a> Finally&#44; although the MID of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min was able to differentiate the change in functional capacity assessed by the 6MWT in the present sample&#44; further studies are suggested to demonstrate the validity of this cutoff point in an independent sample&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusions</span><p id="par0140" class="elsevierStylePara elsevierViewall">In conclusion&#44; the TGlittre is responsible for a PRP and its minimal important difference is &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min &#40;&#8722;0&#46;38 to &#8722;1&#46;05<span class="elsevierStyleHsp" style=""></span>min&#41;&#46; It is recommended to use this minimal important difference only in situations where TGlittre is applied twice&#44; since the learning effect of TGlittre after PRP was about 40&#37; lower than the baseline learning effect&#46; It is suggested that further studies are conducted to determine a TGlittre&#39;s minimal important difference for functional worsening&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Funding</span><p id="par0145" class="elsevierStylePara elsevierViewall">This research was supported in part by the Coordena&#231;&#227;o de Aperfei&#231;oamento de Pessoal de Ensino Superior &#8211; CAPES&#47;Brazil and the Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#8211; CNPq&#47;Brazil &#40;Chamada Universal &#8211; MCTI&#47;CNPq No&#46; 14&#47;2014&#41; and the Funda&#231;&#227;o de Amparo &#224; Pesquisa e Inova&#231;&#227;o do Estado de Santa Catarina &#8211; FAPESC&#47;Brazil &#40;PAP UDESC Chamada Publica No&#46; 01&#47;2016&#46; Grant number 2017TR645&#41;&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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    "fechaRecibido" => "2018-04-19"
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          "clase" => "keyword"
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            0 => "Pulmonary disease"
            1 => "Chronic obstructive"
            2 => "Rehabilitation"
            3 => "Activities of daily living"
            4 => "Exercise test"
            5 => "Outcome assessment"
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    "highlights" => array:2 [
      "titulo" => "Highlights"
      "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0005" class="elsevierStylePara elsevierViewall">Glittre-ADL test minimal important difference &#40;MID&#41; is &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min in COPD patients&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0010" class="elsevierStylePara elsevierViewall">Glittre-ADL test&#39;s MID reflects the changes in functional capacity&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0015" class="elsevierStylePara elsevierViewall">Two tests are necessary for interpretation of changes induced by pulmonary rehabilitation&#46;</p></li></ul></p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine Glittre-ADL test minimal important difference in patients with chronic obstructive pulmonary disease&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">This is quasi-experimental study&#46; Sixty patients with moderate to very severe chronic obstructive pulmonary disease &#40;age 64&#46;1&#44; SD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#46;09 years&#59; forced expiratory volume in the first second 37&#46;9&#44; SD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#46;0&#37; predicted participated in a pulmonary rehabilitation program based on physical training&#44; conducted over 24 sessions supervised&#44; three times a week&#44; including aerobic training in treadmill and resistance training for upper limbs and lower limbs&#46; The main outcomes were the Glittre-ADL test and six-minute walk test&#44; before and after 24 sessions of pulmonary rehabilitation&#46; The minimal important difference was established using the distribution and anchor-based methods&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Patients improved their functional capacity after the pulmonary rehabilitation&#46; The effect sizes of Glittre-ADL test and six-minute walk test improvement were similar &#40;0&#46;45 <span class="elsevierStyleItalic">vs</span> 0&#46;44&#44; respectively&#41;&#46; The established minimal important differences ranged from &#8722;0&#46;38 to &#8722;1&#46;05&#46; The reduction of 0&#46;38<span class="elsevierStyleHsp" style=""></span>min &#40;23<span class="elsevierStyleHsp" style=""></span>s&#41; corresponded to a sensitivity of 64&#37; and a specificity of 69&#37; with an area under the curve of 0&#46;66 &#40;95&#37;CI 0&#46;51&#8211;0&#46;81&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46; Subjects who achieved the minimal important difference of &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min for the Glittre-ADL test had a superior improvement of approximately 42<span class="elsevierStyleHsp" style=""></span>m in the six-minute walk test when compared to patients who did not&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The present findings suggest &#8722;0&#46;38<span class="elsevierStyleHsp" style=""></span>min as the minimal important difference in the time spent in the Glittre-ADL test after 24 sessions of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Trial registration&#58; NCT03251781 &#40;<span class="elsevierStyleInterRef" id="intr0005" href="https://clinicaltrials.gov/ct2/show/NCT03251781">https&#58;&#47;&#47;clinicaltrials&#46;gov&#47;ct2&#47;show&#47;NCT03251781</span>&#41;</p></span>"
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristic curves for change in Glittre-ADL test using the improvement of 30<span class="elsevierStyleHsp" style=""></span>m in the six-minute walk test&#58; AUC of 0&#46;66 &#40;95&#37;CI 0&#46;51&#8211;0&#46;81&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;037&#41;&#44; sensitivity of 64&#37; and specificity of 69&#37;&#46;</p>"
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                  \t\t\t\t">22&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5 times SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5 &#42; SD<span class="elsevierStyleInf">baseline</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#8722;0&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">50&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">MDC&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;96 &#42; sqrt &#40;2&#41; &#42; SEM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;1&#46;05&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">63&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">95&#37;CI&#44; 95&#37; confidence interval&#59; kg&#44; kilograms&#59; m&#44; meters&#59; BMI&#44; body mass index&#59; FEV<span class="elsevierStyleInf">1</span>&#44; forced expiratory volume in one second&#59; FVC&#44; forced vital capacity&#59; L&#44; liter&#59; &#37;pred&#44; percentage of predicted value&#46; GOLD&#44; spirometric classification of the Global Initiative for Chronic Obstructive Lung Disease&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
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                  \t\t\t\t">Age&#44; years&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">64&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">61&#46;8&#8211;66&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Smoking history&#44; pack-years<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">43&#46;0 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#46;3&#8211;59&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Body weight&#44; kg&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">70&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">66&#46;4&#8211;74&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Height&#44; m&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;09&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;62&#8211;1&#46;67&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;5&#8211;27&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FEV<span class="elsevierStyleInf">1</span>&#47;FVC&#44; L&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;46<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;44&#8211;0&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">FEV<span class="elsevierStyleInf">1</span>&#44; L<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;01 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;95&#8211;1&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">FEV<span class="elsevierStyleInf">1</span>&#44; &#37;pred&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#46;5&#8211;41&#46;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FVC&#44; L&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2&#46;17&#8211;2&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FVC&#44; &#37;pred<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#46;1 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">57&#46;0&#8211;83&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GOLD II&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;20&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GOLD III&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">31 &#40;51&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">GOLD IV&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;28&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pre rehabilitation&#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Post rehabilitation&#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#916;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cohen&#39;s <span class="elsevierStyleItalic">d</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean difference&#47;baseline SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TGlittre&#44; min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;67<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;76<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6MWT&#44; m&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">443<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>97&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">485<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>101&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n

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